NIBP, a Novel NIK and IKK -binding Protein That Enhances
نویسندگان
چکیده
From ‡The Miami Project to Cure Paralysis, Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, Florida 33136, the **Neuroscience Program, Miller School of Medicine, University of Miami, Miami, Florida 33136, the ‡‡Laboratory of Hematology, West China Hospital, Sichuan University, Chengdu 610041, China, and the §Department of Physiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298
منابع مشابه
Expression and function of NIK- and IKK2-binding protein (NIBP) in mouse enteric nervous system.
BACKGROUND NIK- and IKK2-binding protein (NIBP)/TRAPPC9 is expressed in brain neurons, and human NIBP mutations are associated with neurodevelopmental disorders. The cellular distribution and function of NIBP in the enteric nervous system (ENS) remain unknown. METHODS Western blot and reverse transcription-polymerase chain reaction analysis were used respectively to identify the protein and m...
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BACKGROUND Despite the identification of many signaling pathways involved in colorectal cancer (CRC) tumorigenesis, metastatic CRC still remains one of the major causes of cancer related death. NIK and IKKβ-binding protein (NIBP) is one of the key regulators of the NF-κB signaling pathway, which has been implicated in CRC metastasis. The aim of this study was to investigate the possible role of...
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Activation of the transcription factor NF-kB by inf lammatory cytokines involves the successive action of NF-kB-inducing kinase (NIK) and two IkB kinases, IKK-a and IKK-b. Here we show that NIK preferentially phosphorylates IKK-a over IKK-b, leading to the activation of IKK-a kinase activity. This phosphorylation of IKK-a occurs specifically on Ser-176 in the activation loop between kinase subd...
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The inflammatory mediators lipopolysaccharide (LPS) and tumor necrosis factor (TNF) are potent activators of NF-kB. This study compared the effect of these stimuli on endogenous IkB kinase (IKK) signalsome activation and IkB phosphorylation/proteolysis in human monocytic cells and investigated the role of the signalsome proteins IKK-a, IKK-b, NF-kB-inducing kinase (NIK), IKK-g (NF-kB essential ...
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تاریخ انتشار 2005